Objective: To determine the characteristics of epithelial-mesenchymal transition(EMT) in different human prostate cancer cell lines and explore the molecular mechanisms of bone metastatic potentials.
目的:对多种转移潜能不同的人前列腺癌细胞“上皮细胞间质转化态”(EMT)特性进行鉴定,并从粘附因素和细胞骨架蛋白角度分析其骨转移潜能获得的分子机制。
Objective:To determine whether human prostate cancer cell lines undergo epithelial-mesenchymal transition(EMT) and become more invasive when induced by HIF-1α,and to explore the underlying molecular mechanism.
目的:研究人前列腺癌细胞在缺氧诱导因子1α(HIF-1α)诱导下能否发生上皮细胞间质转化态(EMT)改变,进而致侵袭能力增强,并初步分析其分子机制。
